Linked Life Data

18359002

Source:http://linkedlifedata.com/resource/pubmed/id/18359002

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-6-23
pubmed:abstractText
Integrins are cell-surface mechanochemical sensors and transducers involved in various cellular processes in combination with extracellular ligands. The aim of this study was to investigate the effect of mechanical stress on the expression of integrinalpha5beta1 and its downstream kinases, focal adhesion kinase (FAK) and integrin-linked kinase (ILK), in condylar cartilage during mandible lateral shift in young rats. Sixty 4-week-old male Wistar rats were divided at random into five control groups and five experimental groups. All rats in the experimental groups were fitted with a resin plate to functionally displace the mandible 2mm to the left (ipsilateral side). The rats were killed 1, 3, 7, 14 and 28 days after attachment of the appliance. Serial 6-mum sagittal sections were cut through the condylar head and processed for immunostaining of integrinalpha5beta1, FAK and ILK. The results were quantified using an image analysing system. Integrinalpha5beta1 expression in the superior-posterior region of the condylar cartilage on the ipsilateral side increased from 3 to 14 days compared with the contralateral side, with an intermediate level of expression in the control groups. Expression of FAK and ILK was similar to integrinalpha5beta1 expression, and they were also upregulated on the ipsilateral side compared with the contralateral side at the early stages of the experiment. The different mechanical loading on the two sides of the condylar cartilage led to different expression patterns of integrinalpha5beta1, FAK and ILK, which may correlate with the different morphological and histological changes seen between sides during mandibular lateral shift.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-9969
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
701-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Expression of integrinalpha5beta1, focal adhesion kinase and integrin-linked kinase in rat condylar cartilage during mandibular lateral displacement.
pubmed:affiliation
Hospital for Stomatology, JiLin University, Changchun, JiLin Province, China. lcwztt@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't