Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-3-24
pubmed:abstractText
Connective tissue growth factor (CTGF, CCN2) is a secreted protein with major roles in angiogenesis, chondrogenesis, osteogenesis, tissue repair, cancer and fibrosis. It is a member of the CCN family of immediate-early gene products which are characterised by four discrete protein modules in which reside growth factor binding domains, functional motifs for integrin recognition, heparin and proteoglycan binding, and dimerization motifs. A primary function of CTGF is to modulate and coordinate signaling responses involving cell surface proteoglycans, key components of the extracellular matrix, and growth factors. Integration of these molecular cues regulates growth factor and receptor interactions, cell motility and mesenchymal cell activation and differentiation in tissue remodelling. Abnormal amplification of CTGF dependent signals results in a failure to terminate tissue repair, leading pathological scarring in conditions such as fibrosis and cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1359-6101
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-44
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:18358427-Amino Acid Motifs, pubmed-meshheading:18358427-Animals, pubmed-meshheading:18358427-Cell Differentiation, pubmed-meshheading:18358427-Connective Tissue Growth Factor, pubmed-meshheading:18358427-Fibrosis, pubmed-meshheading:18358427-Gene Expression Regulation, pubmed-meshheading:18358427-Humans, pubmed-meshheading:18358427-Immediate-Early Proteins, pubmed-meshheading:18358427-Integrins, pubmed-meshheading:18358427-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:18358427-Kidney, pubmed-meshheading:18358427-Models, Biological, pubmed-meshheading:18358427-Models, Genetic, pubmed-meshheading:18358427-Neoplasms, pubmed-meshheading:18358427-Protein Structure, Tertiary, pubmed-meshheading:18358427-Signal Transduction, pubmed-meshheading:18358427-Wound Healing
pubmed:year
2008
pubmed:articleTitle
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis.
pubmed:affiliation
Centre for Rheumatology, Department of Medicine, Hampstead Campus, University College London, Rowland Hill Street, London NW3 2PF, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't