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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-6-26
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pubmed:abstractText |
Age-related macular degeneration (AMD) is the leading cause of vision loss in individuals over the age of 65. Histopathological changes become evident in the retinal pigment epithelium (RPE), a monolayer that provides metabolic support for the overlying photoreceptors, even at the earliest stages of AMD that precede vision loss. In a previous global RPE proteome analysis, changes were identified in the content of several mitochondrial proteins associated with AMD. In this study, the subproteome of mitochondria isolated from human donor RPE graded with the Minnesota Grading System (MGS) was analyzed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex IV,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HSP70 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IMMT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proton-Translocating...,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Elongation Factor Tu,
http://linkedlifedata.com/resource/pubmed/chemical/TUFM protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2848-55
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pubmed:dateRevised |
2010-6-17
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pubmed:meshHeading |
pubmed-meshheading:18344451-Adult,
pubmed-meshheading:18344451-Aged,
pubmed-meshheading:18344451-Aged, 80 and over,
pubmed-meshheading:18344451-Antigens, Neoplasm,
pubmed-meshheading:18344451-Blotting, Western,
pubmed-meshheading:18344451-Disease Progression,
pubmed-meshheading:18344451-Electron Transport Complex IV,
pubmed-meshheading:18344451-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:18344451-Eye Proteins,
pubmed-meshheading:18344451-Female,
pubmed-meshheading:18344451-HSP70 Heat-Shock Proteins,
pubmed-meshheading:18344451-Humans,
pubmed-meshheading:18344451-Isoenzymes,
pubmed-meshheading:18344451-Macular Degeneration,
pubmed-meshheading:18344451-Male,
pubmed-meshheading:18344451-Mass Spectrometry,
pubmed-meshheading:18344451-Middle Aged,
pubmed-meshheading:18344451-Mitochondria,
pubmed-meshheading:18344451-Mitochondrial Proteins,
pubmed-meshheading:18344451-Mitochondrial Proton-Translocating ATPases,
pubmed-meshheading:18344451-Muscle Proteins,
pubmed-meshheading:18344451-Peptide Elongation Factor Tu,
pubmed-meshheading:18344451-Pigment Epithelium of Eye,
pubmed-meshheading:18344451-Proteomics
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pubmed:year |
2008
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pubmed:articleTitle |
Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration.
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pubmed:affiliation |
Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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