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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0033488,
umls-concept:C0085103,
umls-concept:C0109317,
umls-concept:C0205263,
umls-concept:C0531492,
umls-concept:C0752312,
umls-concept:C1120843,
umls-concept:C1150579,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1441547,
umls-concept:C1704259,
umls-concept:C1705767,
umls-concept:C1705791,
umls-concept:C1705987
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pubmed:issue |
9
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pubmed:dateCreated |
2008-7-29
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pubmed:abstractText |
We investigated whether artepillin C, a major component of Brazilian propolis, acts as a neurotrophic-like factor in rat PC12m3 cells, in which nerve growth factor (NGF)-induced neurite outgrowth is impaired. When cultures of PC12m3 cells were treated with artepillin C at a concentration of 20 microM, the frequency of neurite outgrowth induced by artepillin C was approximately 7-fold greater than that induced by NGF alone. Artepillin C induced-neurite outgrowth of PC12m3 cells was inhibited by the ERK inhibitor U0126 and by the p38 MAPK inhibitor SB203580. Although artepillin C-induced p38 MAPK activity was detected in PC12m3 cells, phosphorylation of ERK induced by artepillin C was not observed. On the other hand, artepillin C caused rapid activation of ERK and the time course of the activation was similar to that induced by NGF treatment in PC12 parental cells. However, NGF-induced neurite outgrowth was inhibited by artepillin C treatment. Interestingly, inhibition of ERK by U0126 completely prevented artepillin C-induced p38 MAPK phosphorylation of PC12m3 cells. These findings suggest that artepillin C-induced activation of p38 MAPK through the ERK signaling pathway is responsible for the neurite outgrowth of PC12m3 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleic Acid Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylpropionates,
http://linkedlifedata.com/resource/pubmed/chemical/Propolis,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridones,
http://linkedlifedata.com/resource/pubmed/chemical/artepillin C,
http://linkedlifedata.com/resource/pubmed/chemical/militarinone A,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1573-6903
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pubmed:author |
pubmed-author:AkiyamaJunichiJ,
pubmed-author:AramakiFumikaF,
pubmed-author:DoiShimaS,
pubmed-author:EguchiSueoS,
pubmed-author:HashimotoKenK,
pubmed-author:HiragamiFukumiF,
pubmed-author:HorieNoboruN,
pubmed-author:KanoYoshioY,
pubmed-author:KawamuraKenjiK,
pubmed-author:KoikeYoshihisaY,
pubmed-author:MaedaHidefumiH,
pubmed-author:MotodaHirotoshiH
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1795-803
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18338254-Alkaloids,
pubmed-meshheading:18338254-Animals,
pubmed-meshheading:18338254-Anti-Infective Agents,
pubmed-meshheading:18338254-Apoptosis,
pubmed-meshheading:18338254-Enzyme Activation,
pubmed-meshheading:18338254-Enzyme Inhibitors,
pubmed-meshheading:18338254-Humans,
pubmed-meshheading:18338254-MAP Kinase Signaling System,
pubmed-meshheading:18338254-Mice,
pubmed-meshheading:18338254-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:18338254-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:18338254-Molecular Structure,
pubmed-meshheading:18338254-Neurites,
pubmed-meshheading:18338254-Nucleic Acid Synthesis Inhibitors,
pubmed-meshheading:18338254-PC12 Cells,
pubmed-meshheading:18338254-Phenylpropionates,
pubmed-meshheading:18338254-Propolis,
pubmed-meshheading:18338254-Pyridones,
pubmed-meshheading:18338254-Rats,
pubmed-meshheading:18338254-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2008
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pubmed:articleTitle |
Artepillin C derived from propolis induces neurite outgrowth in PC12m3 cells via ERK and p38 MAPK pathways.
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pubmed:affiliation |
Department of Occupational Therapy, School of Health Science, Kibi International University, 8 Iga-machi, Takahashi-city, Okayama, 716-8508, Japan. yoshio@kiui.ac.jp
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pubmed:publicationType |
Journal Article
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