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rdf:type |
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lifeskim:mentions |
umls-concept:C0003075,
umls-concept:C0205054,
umls-concept:C0205234,
umls-concept:C0243144,
umls-concept:C0291786,
umls-concept:C0442027,
umls-concept:C0596902,
umls-concept:C0747055,
umls-concept:C0935929,
umls-concept:C1305923,
umls-concept:C1704675
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pubmed:issue |
6
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pubmed:dateCreated |
2008-5-30
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pubmed:abstractText |
The uptake of drugs into hepatocytes is a key determinant for hepatic metabolism, intrahepatic action, their subsequent systemic plasma concentrations, and extrahepatic actions. In vitro and in vivo studies indicate that many drugs used for treatment of cardiovascular diseases (e.g., oral antidiabetic drugs, statins) are taken up into hepatocytes by distinct organic anion transporters (organic anion transporting polypeptides [OATPs]; gene symbol SLCO/SLC21) or organic cation transporters (OCTs; gene symbol SLC22). Because most patients with type 2 diabetes receive more than one drug and inhibition of drug transporters has been recognized as a new mechanism underlying drug-drug interactions, we tested the hypothesis of whether oral antidiabetic drugs can inhibit the transport mediated by hepatic uptake transporters.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carbamates,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Metformin,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Anion Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Anion Transporters...,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pravastatin,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SLCO1B1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SLCO1B3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/repaglinide,
http://linkedlifedata.com/resource/pubmed/chemical/rosiglitazone
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1463-9
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pubmed:meshHeading |
pubmed-meshheading:18314419-Administration, Oral,
pubmed-meshheading:18314419-Animals,
pubmed-meshheading:18314419-Biological Transport,
pubmed-meshheading:18314419-Carbamates,
pubmed-meshheading:18314419-Cell Line,
pubmed-meshheading:18314419-Dogs,
pubmed-meshheading:18314419-Hepatocytes,
pubmed-meshheading:18314419-Humans,
pubmed-meshheading:18314419-Hypoglycemic Agents,
pubmed-meshheading:18314419-Kidney,
pubmed-meshheading:18314419-Kinetics,
pubmed-meshheading:18314419-Liver,
pubmed-meshheading:18314419-Metformin,
pubmed-meshheading:18314419-Organic Anion Transporters,
pubmed-meshheading:18314419-Organic Anion Transporters, Sodium-Independent,
pubmed-meshheading:18314419-Piperidines,
pubmed-meshheading:18314419-Pravastatin,
pubmed-meshheading:18314419-Recombinant Proteins,
pubmed-meshheading:18314419-Thiazolidinediones
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pubmed:year |
2008
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pubmed:articleTitle |
Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.
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pubmed:affiliation |
Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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