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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-19
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pubmed:abstractText |
A recent clinical trial demonstrated that selective progesterone receptor modulator asoprisnil is effective in reducing uterine leiomyoma volume. We investigated the effects of asoprisnil in vitro on the expression of the extracellular matrix (ECM)-remodeling enzymes and collagens in cultured leiomyoma and matching normal myometrial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1460-2350
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
944-51
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pubmed:meshHeading |
pubmed-meshheading:18281245-Adult,
pubmed-meshheading:18281245-Antigens, CD147,
pubmed-meshheading:18281245-Cells, Cultured,
pubmed-meshheading:18281245-Collagen,
pubmed-meshheading:18281245-Down-Regulation,
pubmed-meshheading:18281245-Estrenes,
pubmed-meshheading:18281245-Female,
pubmed-meshheading:18281245-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:18281245-Humans,
pubmed-meshheading:18281245-Leiomyoma,
pubmed-meshheading:18281245-Matrix Metalloproteinases,
pubmed-meshheading:18281245-Middle Aged,
pubmed-meshheading:18281245-Myometrium,
pubmed-meshheading:18281245-Oximes,
pubmed-meshheading:18281245-Receptors, Progesterone,
pubmed-meshheading:18281245-Tissue Inhibitor of Metalloproteinases,
pubmed-meshheading:18281245-Up-Regulation,
pubmed-meshheading:18281245-Uterine Neoplasms
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pubmed:year |
2008
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pubmed:articleTitle |
Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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