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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-4-23
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pubmed:abstractText |
Existing serum markers for breast cancer such as CA 15-3, BR 27.29 and CEA lack sensitivity and specificity. The aim of this study was to evaluate the value of new putative breast-specific markers for differentiating breast cancer from non-breast tissues. Expression of mammaglobin A (MGA), B726P, small breast epithelial mucin (SBEM) and MUC1 was measured by RT-PCR. MGA mRNA was detected in 86/162 (60%) breast cancers but in only 1/32 (3%) non-breast tissues; B726P was detected in 44/108 (41%) breast cancers but in none of 20 non-breast tissues, while SBEM was present in 52/103 (51%) breast cancers but in only 1/26 non-breast cancer tissues. In contrast to these novel markers, the established breast cancer marker MUC1 was detected in 72/99 (73%) breast cancers and in 22/32 (59%) of non-breast tissues. Combining MGA with B726P separated breast cancer from non-breast tissue with a sensitivity of 71% and a specificity of 95% while combining MGA with SBEM differentiated breast cancer from non-breast tissues with a sensitivity of 76% and a specificity of 89%. Genes such as MGA, B726P and SBEM that are expressed relatively exclusively in breast tissue are potential new markers for breast cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/MUC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MUCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mammaglobin A,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Mucins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/SCGB2A2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Uteroglobin
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0380
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
312-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18253069-Breast Neoplasms,
pubmed-meshheading:18253069-Carcinoma, Ductal, Breast,
pubmed-meshheading:18253069-Carcinoma, Lobular,
pubmed-meshheading:18253069-DNA Primers,
pubmed-meshheading:18253069-Female,
pubmed-meshheading:18253069-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18253069-Humans,
pubmed-meshheading:18253069-Mammaglobin A,
pubmed-meshheading:18253069-Middle Aged,
pubmed-meshheading:18253069-Mucin-1,
pubmed-meshheading:18253069-Mucins,
pubmed-meshheading:18253069-Neoplasm Proteins,
pubmed-meshheading:18253069-RNA, Messenger,
pubmed-meshheading:18253069-Receptors, Estrogen,
pubmed-meshheading:18253069-Receptors, Progesterone,
pubmed-meshheading:18253069-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18253069-Sensitivity and Specificity,
pubmed-meshheading:18253069-Tissue Distribution,
pubmed-meshheading:18253069-Tumor Markers, Biological,
pubmed-meshheading:18253069-Uteroglobin
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pubmed:year |
2007
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pubmed:articleTitle |
Use of a panel of novel genes for differentiating breast cancer from non-breast tissues.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, St. Vincent's University Hospital, Dublin, Ireland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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