|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001721,
umls-concept:C0010346,
umls-concept:C0030705,
umls-concept:C0032529,
umls-concept:C0597357,
umls-concept:C0666743,
umls-concept:C0871261,
umls-concept:C1456820,
umls-concept:C1556094,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1883220,
umls-concept:C2911692
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2008-4-2
|
|
pubmed:abstractText |
Tumour necrosis factor alpha is the key inflammatory cytokine involved in the pathogenesis of Crohn's disease. Infliximab, a chimaeric monoclonal antibody of tumour necrosis factor-alpha is successfully used for the treatment of Crohn's disease, although the response to infliximab therapy differs among patients. The genetic background of the individual may partially explain the differences of the responsiveness.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1365-2036
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
765-70
|
|
pubmed:meshHeading |
pubmed-meshheading:18248655-Adult,
pubmed-meshheading:18248655-Antibodies, Monoclonal,
pubmed-meshheading:18248655-Asian Continental Ancestry Group,
pubmed-meshheading:18248655-Crohn Disease,
pubmed-meshheading:18248655-Female,
pubmed-meshheading:18248655-Genetic Predisposition to Disease,
pubmed-meshheading:18248655-Genotype,
pubmed-meshheading:18248655-Humans,
pubmed-meshheading:18248655-Male,
pubmed-meshheading:18248655-Polymorphism, Genetic,
pubmed-meshheading:18248655-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:18248655-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:18248655-Regression Analysis
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Genetic polymorphisms of tumour necrosis factor receptor superfamily 1A and 1B affect responses to infliximab in Japanese patients with Crohn's disease.
|
|
pubmed:affiliation |
Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
|
|
pubmed:publicationType |
Journal Article
|
