Linked Life Data

18248349

Source:http://linkedlifedata.com/resource/pubmed/id/18248349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-6
pubmed:abstractText
The synthesis and characterization of a novel macrocyclic polyamine cationic lipid containing an imidazolium salt group is reported. Its interaction with plasmid DNA was studied by gel electrophoresis and fluorescence quenching experiments. The transfection activity of target compound as a gene delivery vector was also investigated. The results showed that the synthesized macrocyclic polyamine cationic lipid has high binding and condensation ability of DNA under physiological conditions probably because of the cooperation effect of macrocyclic polyamine (Cyclen) and an imidazolium salt group. This novel lipid could transfer plasmid DNA into cell in in vitro experiment without the use of any extraneous agent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1747-0285
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
224-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
A novel macrocyclic polyamine cationic lipid containing an imidazolium salt group: synthesis, characterization and its transfection activity as a gene delivery vector.
pubmed:affiliation
Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu, Sichuan 610064, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't