Linked Life Data

18243649

Source:http://linkedlifedata.com/resource/pubmed/id/18243649

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-3-5
pubmed:abstractText
This is a mini-review summarizing recent findings on the effect of flutamide (FLUT), an anti-androgenic toxicant, on the mouse testis, particularly on the ectoplasmic specialization (ES) in the testis. FLUT induces a reduction in the weight of male reproductive tissues, such as the prostate, because it inhibits the formation of the androgen receptors and testosterone retention. The present review summarizes the abnormal histological changes produced in the mouse testis by FLUT. In addition, we outline the effect of FLUT on the expression of cortactin, an actin-binding protein, in the mouse testis. FLUT is often used as a positive control for the identification of endocrine disrupting chemicals having anti-androgenic activities; therefore, a detailed understanding of the adverse effects of FLUT is important for the analysis of the risks to spermatogenesis by anti-androgen-like endocrine disruptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0890-6238
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-43
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Review of the histological effects of the anti-androgen, flutamide, on mouse testis.
pubmed:affiliation
Faculty of Health Sciences, Ryotokuji University, 5-8-1, Akemi, Urayasu, Chiba 279-8567, Japan. re-anahara@ryotokuji-u.ac.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't