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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-2-26
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pubmed:abstractText |
R-spondins are a new group of Wnt/beta-catenin signaling agonists, however, the role of these proteins in bone remains unclear. We reported herein that R-sponin1 (Rspo1) acted synergistically with Wnt3A to activate Wnt/beta-catenin signaling in the uncommitted mesenchymal C2C12 cells. Furthermore, we found that Rspo1 at concentrations as low as 10 ng/ml synergized strongly with Wnt3A to induce C2C12 osteoblastic differentiation and osteoprotegerin expression. These events were blocked by Wnt/beta-catenin signaling antagonist Dickkopf-1. Finally, we demonstrated that Rspo1 synergized with Wnt3A to induce primary mouse osteoblast differentiation. Together, these findings suggest that Rpos1 may play an important role in bone remodeling.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/DKK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/LDL-Receptor Related Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LRP6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Low Density Lipoprotein...,
http://linkedlifedata.com/resource/pubmed/chemical/Lrp6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Osteoprotegerin,
http://linkedlifedata.com/resource/pubmed/chemical/RSPO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RSPO1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombospondins,
http://linkedlifedata.com/resource/pubmed/chemical/WNT3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3A Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
582
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
643-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18242177-Alkaline Phosphatase,
pubmed-meshheading:18242177-Animals,
pubmed-meshheading:18242177-Animals, Newborn,
pubmed-meshheading:18242177-Cell Differentiation,
pubmed-meshheading:18242177-Cell Line,
pubmed-meshheading:18242177-Culture Media, Conditioned,
pubmed-meshheading:18242177-Gene Expression Regulation,
pubmed-meshheading:18242177-Humans,
pubmed-meshheading:18242177-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18242177-LDL-Receptor Related Proteins,
pubmed-meshheading:18242177-Low Density Lipoprotein Receptor-Related Protein-6,
pubmed-meshheading:18242177-Mice,
pubmed-meshheading:18242177-Osteoblasts,
pubmed-meshheading:18242177-Osteoprotegerin,
pubmed-meshheading:18242177-Phosphorylation,
pubmed-meshheading:18242177-Thermodynamics,
pubmed-meshheading:18242177-Thrombospondins,
pubmed-meshheading:18242177-Time Factors,
pubmed-meshheading:18242177-Wnt Proteins,
pubmed-meshheading:18242177-Wnt3 Protein,
pubmed-meshheading:18242177-Wnt3A Protein,
pubmed-meshheading:18242177-beta Catenin
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pubmed:year |
2008
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pubmed:articleTitle |
R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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