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pubmed-article:18211821pubmed:abstractTextWe identified a Drosophila homologue that belongs to a subfamily of the mammalian peroxiredoxin 5 genes. The Drosophila peroxiredoxin 5 (dPrx 5) gene corresponds to CG7217 (FlyBase nomenclature), and exhibits identical polarity to that of the nearby upstream CG7215 gene, for which the deduced amino acid sequence reveals an ubiquitin-like domain at the N-terminus. The tandem pattern of the arrangement of these two genes is well-conserved among the Drosophilids. In addition to CG7215 and dPrx5 gene-specific transcripts that could be transcribed independently from two distinct promoters, transcripts spanning both coding regions have been identified, leading to the characterization of this gene cluster as a dicistronic operon. The different transcripts exhibit stage-specific accumulation patterns. While the upstream CG7215 gene can be expressed from both mono- and dicistronic mRNAs, the downstream dPrx5 gene is likely to be expressed predominantly from its monocistronic transcripts.lld:pubmed
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pubmed-article:18211821pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:18211821pubmed:articleTitleDrosophila peroxiredoxin 5 is the second gene in a dicistronic operon.lld:pubmed
pubmed-article:18211821pubmed:affiliationDepartment of Biological Sciences, Southern Methodist University, 6501 Airline, Dedman Life Sciences Building, Room 113, Dallas, TX 75275, USA.lld:pubmed
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pubmed-article:18211821pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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