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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-25
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pubmed:abstractText |
We identified a Drosophila homologue that belongs to a subfamily of the mammalian peroxiredoxin 5 genes. The Drosophila peroxiredoxin 5 (dPrx 5) gene corresponds to CG7217 (FlyBase nomenclature), and exhibits identical polarity to that of the nearby upstream CG7215 gene, for which the deduced amino acid sequence reveals an ubiquitin-like domain at the N-terminus. The tandem pattern of the arrangement of these two genes is well-conserved among the Drosophilids. In addition to CG7215 and dPrx5 gene-specific transcripts that could be transcribed independently from two distinct promoters, transcripts spanning both coding regions have been identified, leading to the characterization of this gene cluster as a dicistronic operon. The different transcripts exhibit stage-specific accumulation patterns. While the upstream CG7215 gene can be expressed from both mono- and dicistronic mRNAs, the downstream dPrx5 gene is likely to be expressed predominantly from its monocistronic transcripts.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-10521424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-10679306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-10751410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-10753630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-10917590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-11677042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-12556226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-12782306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-14732291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-15304327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-15642184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-15848167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-15951443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-16817890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18211821-9155028
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1090-2104
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
368
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18211821-Animals,
pubmed-meshheading:18211821-Base Sequence,
pubmed-meshheading:18211821-Drosophila,
pubmed-meshheading:18211821-Genes,
pubmed-meshheading:18211821-Molecular Sequence Data,
pubmed-meshheading:18211821-Operon,
pubmed-meshheading:18211821-Organ Specificity,
pubmed-meshheading:18211821-Peroxiredoxins,
pubmed-meshheading:18211821-Promoter Regions, Genetic,
pubmed-meshheading:18211821-Tissue Distribution
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pubmed:year |
2008
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pubmed:articleTitle |
Drosophila peroxiredoxin 5 is the second gene in a dicistronic operon.
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pubmed:affiliation |
Department of Biological Sciences, Southern Methodist University, 6501 Airline, Dedman Life Sciences Building, Room 113, Dallas, TX 75275, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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