Source:http://linkedlifedata.com/resource/pubmed/id/18206417
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2008-5-2
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| pubmed:abstractText |
Tobacco-related oral squamous cell carcinoma is a common malignancy in Asian people. It accounts for almost 40% of cancers among Indian men and 3% in the Western world. Smokeless tobacco has been shown to induce tumor necrosis factor-alpha (TNF-alpha), which, along with its receptors, is over-expressed in people with oral carcinoma. Single nucleotide polymorphisms (SNPs) in TNF-alpha and TNF receptor genes may affect their expression and may be a potential determinant of susceptibility to tobacco-related oral carcinomas. We assessed SNPs in TNF-alpha(-308, -238) and TNF receptor 1 (TNFR1; -609) promoters by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and at four sites of TNF receptor 2 gene (TNFR2; exon 9 site 1176; exon 10 sites 1663, 1668 and 1690) by PCR-sequence-specific primers (PCR-SSP) techniques, respectively, in 94 patients and 130 healthy controls. TNF-alpha-308 G allele was significantly lower (Pc=0.004; OR=3.85), whereas A allele was significantly higher (Pc=0.004; OR=0.25) in patients compared with controls. No significant change was observed at -238 promoter site between the two groups. In the case of TNF receptors, both TNFR1 -609 TT (Pc=0.006; OR=15.3) and TNFR2 1690 CT (Pc=0.018; OR=5.6) genotypes were significantly lower in patients compared with controls. It seems that TNF-alpha-308 G/A may be related to susceptibility, whereas -609 TT TNFR1 and 1690 C/T TNFR2 SNPs may be protective to tobacco-related oral squamous cell carcinoma. These SNPs may be useful as a marker for high-risk groups among Asian Indians.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1368-8375
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
44
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
455-63
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| pubmed:meshHeading |
pubmed-meshheading:18206417-Adult,
pubmed-meshheading:18206417-Aged,
pubmed-meshheading:18206417-Asian Continental Ancestry Group,
pubmed-meshheading:18206417-Carcinoma, Squamous Cell,
pubmed-meshheading:18206417-Case-Control Studies,
pubmed-meshheading:18206417-Female,
pubmed-meshheading:18206417-Genetic Predisposition to Disease,
pubmed-meshheading:18206417-Humans,
pubmed-meshheading:18206417-India,
pubmed-meshheading:18206417-Male,
pubmed-meshheading:18206417-Middle Aged,
pubmed-meshheading:18206417-Mouth Neoplasms,
pubmed-meshheading:18206417-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:18206417-Polymorphism, Single Nucleotide,
pubmed-meshheading:18206417-Promoter Regions, Genetic,
pubmed-meshheading:18206417-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:18206417-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:18206417-Tobacco, Smokeless,
pubmed-meshheading:18206417-Tumor Necrosis Factor-alpha
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| pubmed:year |
2008
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| pubmed:articleTitle |
Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians.
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| pubmed:affiliation |
Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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