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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-21
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pubmed:abstractText |
Cysteinyl-leukotrienes are important pro-inflammatory mediators in bronchial asthma (BA) and are derived from arachidonic acid by the action of 5-lipoxygenase. We identified a novel polymorphism, c.760 G>A (E254K), in exon 6 of the 5-lipoxygenase gene (5-LO). This substitution was detected in 11 out of 180 patients with BA, but not in any of the 150 non-allergic subjects. The frequency of c.760 G>A showed a significant difference between BA and non-allergic subjects (P=0.0007). The c.760 G>A polymorphism existed at the surface edge of the C-terminal catalytic domain, and the E-to-K substitution changed the charge of the side chain from negative to positive. Thus, our results suggest that E254K in the 5-LO might be associated with BA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1107-3756
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
139-44
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pubmed:meshHeading |
pubmed-meshheading:18204779-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:18204779-Asthma,
pubmed-meshheading:18204779-Base Sequence,
pubmed-meshheading:18204779-Child,
pubmed-meshheading:18204779-DNA Mutational Analysis,
pubmed-meshheading:18204779-Female,
pubmed-meshheading:18204779-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:18204779-Gene Frequency,
pubmed-meshheading:18204779-Genetic Predisposition to Disease,
pubmed-meshheading:18204779-Glutamic Acid,
pubmed-meshheading:18204779-Humans,
pubmed-meshheading:18204779-Ionomycin,
pubmed-meshheading:18204779-Leukotriene B4,
pubmed-meshheading:18204779-Leukotriene E4,
pubmed-meshheading:18204779-Lysine,
pubmed-meshheading:18204779-Male,
pubmed-meshheading:18204779-Models, Molecular,
pubmed-meshheading:18204779-Molecular Sequence Data,
pubmed-meshheading:18204779-Neutrophils,
pubmed-meshheading:18204779-Polymorphism, Genetic,
pubmed-meshheading:18204779-RNA, Messenger,
pubmed-meshheading:18204779-Structural Homology, Protein
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pubmed:year |
2008
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pubmed:articleTitle |
A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.
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pubmed:affiliation |
Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501-1193, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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