Linked Life Data

18197556

Source:http://linkedlifedata.com/resource/pubmed/id/18197556

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-16
pubmed:abstractText
Quantitative reverse-transcription polymerase chain reaction (RT-PCR) and Western blot analyses were carried out to investigate the regulation of genes responsible for the transport and metabolism of drugs in response to different levels of salt intake. A high-salt diet compared with medium- and low-salt diets reduced the expression levels of the mdr1a and mdr1b genes in the liver and kidney, but increased their expression levels in the duodenum, jejunum, and ileum. Likewise, the expression levels of other transporters and CYP3a3 genes varied in different tissues. The expression levels of nuclear receptors, such as Pxr, Fxr, and Car, were also modulated differently in the liver, kidney, and intestines. The protein levels of Mdr1, Oct1, CYP3a, Pxr, Fxr, and Car were correlated with the changes in mRNA levels of the respective genes. In conclusion, the changes in the expression of drug transporters, metabolic enzymes, and nuclear receptors were tissue specific.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-55
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Effects of dietary salt on the expression of drug transporters, cytochrome P4503a, and nuclear receptors in rats.
pubmed:affiliation
Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't