| pubmed-article:18191896 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C0027836 | lld:lifeskim |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C0035298 | lld:lifeskim |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C0013117 | lld:lifeskim |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C1825644 | lld:lifeskim |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:18191896 | lifeskim:mentions | umls-concept:C1880218 | lld:lifeskim |
| pubmed-article:18191896 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18191896 | pubmed:dateCreated | 2008-2-18 | lld:pubmed |
| pubmed-article:18191896 | pubmed:abstractText | In the adult retina, N-methyl-D-aspartate (NMDA) neurotoxicity induces Müller cell reactive gliosis which is characterized by changes in gene expression that lead to proliferation and affect retinal physiology. The amino acid D-serine is synthesized in Müller cells and modulates these processes acting as a coagonist of NMDA receptors. We have found that the transcription factor DREAM (downstream regulatory element antagonist modulator), which acts as a transcriptional repressor by binding as a tetramer to regulatory elements located in the promoter region of target genes, is expressed in these cells and that its DNA-binding activity is modulated by NMDA receptor activation. Consistently, immunocytochemical analysis demonstrates that NMDA receptor activation induces changes in the nuclear localization of this transcription factor. DREAM is a pleiotropic transcription factor capable to repress and activate genes involved in several physiological events in different tissues. These results link, for the first time, this transcription factor with NMDA-receptor activation. Given the relevance of glutamatergic transmission in the retina and the remarkable functional plasticity of Müller cells, these findings support the notion that the NMDA receptor-dependent modulation of DREAM activity could play a role in relevant physiological processes ranging from retinal response to injury to differentiation capacity of retinal progenitor cells. | lld:pubmed |
| pubmed-article:18191896 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18191896 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18191896 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18191896 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18191896 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18191896 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18191896 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18191896 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:18191896 | pubmed:author | pubmed-author:LamasMónicaM | lld:pubmed |
| pubmed-article:18191896 | pubmed:author | pubmed-author:RamírezMónica... | lld:pubmed |
| pubmed-article:18191896 | pubmed:author | pubmed-author:Chavira-Suáre... | lld:pubmed |
| pubmed-article:18191896 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18191896 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:18191896 | pubmed:volume | 432 | lld:pubmed |
| pubmed-article:18191896 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18191896 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18191896 | pubmed:pagination | 121-6 | lld:pubmed |
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| pubmed-article:18191896 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18191896 | pubmed:articleTitle | D-Serine/N-methyl-D-aspartate receptor signaling decreases DNA-binding activity of the transcriptional repressor DREAM in Müller glia from the retina. | lld:pubmed |
| pubmed-article:18191896 | pubmed:affiliation | Departamento de Farmacobiología, Cinvestav Sede Sur, México DF, Mexico. | lld:pubmed |
| pubmed-article:18191896 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:65199 | entrezgene:pubmed | pubmed-article:18191896 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18191896 | lld:pubmed |
