Source:http://linkedlifedata.com/resource/pubmed/id/18171606
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2008-3-18
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| pubmed:abstractText |
We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma. Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinicopathological parameters, including 5-year survival. Increased COX-2 staining pattern correlated with a non-mucinous histological type (p=0.008), increased stage (p<0.0001), high histological grade (p<0.0001), and reduced survival rates (p<0.00001). Survivin expression was strongly associated with increased stage (p<0.0001), increased histological grade (p<0.0001), and reduced survival (p<0.00001). Elevated survivin expression also correlated significantly with pre-menopausal status (p=0.033). In addition, COX-2 and survivin staining patterns correlated strongly with one another (p<0.0001). However, on multivariate analysis, an independent prognostic value was found only for tumor stage and grade. The findings of our study indicate that the increased expression of COX-2 and survivin in ovarian cancer is associated with one another and with several adverse clinicopathologic parameters, including reduced survival, thus suggesting a role of these molecules in disease progression. Further investigations of the exact prognostic and therapeutic implications of COX-2 and survivin expression are strongly warranted.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0344-0338
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
204
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
241-9
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:18171606-Adult,
pubmed-meshheading:18171606-Aged,
pubmed-meshheading:18171606-Aged, 80 and over,
pubmed-meshheading:18171606-Cyclooxygenase 2,
pubmed-meshheading:18171606-Disease Progression,
pubmed-meshheading:18171606-Female,
pubmed-meshheading:18171606-Humans,
pubmed-meshheading:18171606-Immunohistochemistry,
pubmed-meshheading:18171606-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:18171606-Kaplan-Meier Estimate,
pubmed-meshheading:18171606-Microtubule-Associated Proteins,
pubmed-meshheading:18171606-Middle Aged,
pubmed-meshheading:18171606-Neoplasm Proteins,
pubmed-meshheading:18171606-Neoplasm Staging,
pubmed-meshheading:18171606-Ovarian Neoplasms,
pubmed-meshheading:18171606-Proportional Hazards Models,
pubmed-meshheading:18171606-Prospective Studies,
pubmed-meshheading:18171606-Risk Assessment,
pubmed-meshheading:18171606-Time Factors,
pubmed-meshheading:18171606-Treatment Outcome,
pubmed-meshheading:18171606-Tumor Markers, Biological,
pubmed-meshheading:18171606-Up-Regulation
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| pubmed:year |
2008
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| pubmed:articleTitle |
The prognostic significance of COX-2 and survivin expression in ovarian cancer.
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| pubmed:affiliation |
Pathology Laboratory, Cytology Department, Medical School, Athens University, 75 Mikras Asias Street, 11527 Athens, Greece. dimgrap@yahoo.gr
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| pubmed:publicationType |
Journal Article
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