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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-12-31
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pubmed:abstractText |
Tubular dysfunction is a hallmark of severe leptospirosis. Antimicrobial therapy is thought to interfere on renal involvement. We evaluated the expression of a proximal tubule type-3 Na+/H+ exchanger (NHE3) and a thick ascending limb Na+-K+-2Cl(-) cotransporter (NKCC2) in controls and treated hamsters. Animals infected by a serovar Copenhageni isolate, were treated or not with ampicillin (AMP) and/or N-acetylcysteine (NAC). Leptospiral antigen(s) and expression of renal transporters were evaluated by immunohistochemistry, and serum thiobarbituric acid (TBARS) was quantified. Infected hamsters had high amounts of detectable leptospiral antigen(s) in target tissues while renal expression of NHE3 and NKCC2 decreased. Ampicillin treatment was associated with minimal or no detection of leptospiral antigens, normal expression of NHE3 and NKCC2 transporters, and reduced levels of TBARS. NAC effect was restricted to lowering TBARS. Early and late AMP treatment rescued tubular defects in severe leptospirosis disease, and there was no evidence of benefit from antioxidant therapy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Ampicillin,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Hydrogen Antiporter,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Chloride Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbiturates,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-hydrogen exchanger 3,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-potassium chloride...,
http://linkedlifedata.com/resource/pubmed/chemical/thiobarbituric acid
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9637
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1111-9
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pubmed:meshHeading |
pubmed-meshheading:18165532-Acetylcysteine,
pubmed-meshheading:18165532-Ampicillin,
pubmed-meshheading:18165532-Animals,
pubmed-meshheading:18165532-Anti-Bacterial Agents,
pubmed-meshheading:18165532-Antigens, Bacterial,
pubmed-meshheading:18165532-Cricetinae,
pubmed-meshheading:18165532-Down-Regulation,
pubmed-meshheading:18165532-Female,
pubmed-meshheading:18165532-Free Radical Scavengers,
pubmed-meshheading:18165532-Gene Expression Profiling,
pubmed-meshheading:18165532-Gene Expression Regulation,
pubmed-meshheading:18165532-Kidney,
pubmed-meshheading:18165532-Liver,
pubmed-meshheading:18165532-Mesocricetus,
pubmed-meshheading:18165532-Sodium-Hydrogen Antiporter,
pubmed-meshheading:18165532-Sodium-Potassium-Chloride Symporters,
pubmed-meshheading:18165532-Thiobarbiturates,
pubmed-meshheading:18165532-Weil Disease
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pubmed:year |
2007
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pubmed:articleTitle |
Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy.
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pubmed:affiliation |
Department of Nephrology, Laboratorio Pesquisa Basica LIM 12, Faculdade de Medicina USP, University of São Paulo School of Medicine, São Paulo, Brazil. annespichler@terra.com.br
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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