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rdf:type |
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lifeskim:mentions |
umls-concept:C0007303,
umls-concept:C0007452,
umls-concept:C0009331,
umls-concept:C0017262,
umls-concept:C0037903,
umls-concept:C0086982,
umls-concept:C0109317,
umls-concept:C0185117,
umls-concept:C0225369,
umls-concept:C0547047,
umls-concept:C0752312,
umls-concept:C1150579,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1705767,
umls-concept:C1705791,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-21
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pubmed:abstractText |
Ceramide, a mediator of proinflammatory cytokine signaling, induces cartilage degradation and reduces type II collagen synthesis in articular cartilage. The accumulation of ceramide is associated with arthritis in Farber's disease. The aim of this study was to investigate the mechanism of ceramide-induced down-regulation of type II collagen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-raf,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SOX9 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingomyelin Phosphodiesterase,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-20
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18163502-Animals,
pubmed-meshheading:18163502-Cartilage, Articular,
pubmed-meshheading:18163502-Cattle,
pubmed-meshheading:18163502-Cells, Cultured,
pubmed-meshheading:18163502-Chondrocytes,
pubmed-meshheading:18163502-Collagen Type II,
pubmed-meshheading:18163502-Culture Media,
pubmed-meshheading:18163502-Down-Regulation,
pubmed-meshheading:18163502-Genes, Immediate-Early,
pubmed-meshheading:18163502-High Mobility Group Proteins,
pubmed-meshheading:18163502-MAP Kinase Kinase 1,
pubmed-meshheading:18163502-MAP Kinase Kinase 2,
pubmed-meshheading:18163502-MAP Kinase Signaling System,
pubmed-meshheading:18163502-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:18163502-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:18163502-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:18163502-Proto-Oncogene Proteins c-raf,
pubmed-meshheading:18163502-RNA, Messenger,
pubmed-meshheading:18163502-SOX9 Transcription Factor,
pubmed-meshheading:18163502-Sphingomyelin Phosphodiesterase,
pubmed-meshheading:18163502-Transcription Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway.
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pubmed:affiliation |
Cardiff University, Cardiff, Wales, UK. GilbertSJ1@Cardiff.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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