Linked Life Data

18162231

Source:http://linkedlifedata.com/resource/pubmed/id/18162231

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Suppl 1
pubmed:dateCreated
2007-12-28
pubmed:abstractText
An analysis of NMDP data shows that allele-level matching for HLA A, B, C, and DRB1 is preferred in the selection of adult unrelated donors. If mismatching is unavoidable, mismatches at HLA B or C may be better tolerated than those at A or DRB1. Whether mismatches are at the allele level (ie, within an antigen group) or at the antigen level makes no difference in outcome, except at HLA C where allele mismatches are better tolerated. Matching for HLA DQ and DP should be prioritized below matching at the 4 major loci. These findings are compared and contrasted with previous publications. The impact of HLA matching on major outcomes in umbilical cord blood (UCB) transplantation continues to be refined. Total nucleated cell dose was previously thought to be sole determinant of outcome with partially HLA matched UCB transplantation, but HLA matching, particularly at low total nucleated cell dose, appears to play an important role. Relatively small sample sizes limit the consistency of findings from cord blood studies, but the consensus supports consideration of both total nucleated cell dose and HLA matching in the selection of optimal UCB units. As search considerations for both adult donors and umbilical cord blood units have become more complex, the National Marrow Donor Program has developed software, services and relationships to ease the burden on transplant teams.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1523-6536
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Principles and tools for selection of umbilical cord blood and unrelated adult donor grafts.
pubmed:affiliation
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
pubmed:publicationType
Journal Article, Review