Linked Life Data

18155139

Source:http://linkedlifedata.com/resource/pubmed/id/18155139

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-1-29
pubmed:abstractText
Polyhydroxyalkanoate (PHA) copolymers of poly[(R)-3-hydroxybutyrate-co-5mol%-(R)-3-hydroxyhexanoate], poly[(R)-3-hydroxybutyrate-co-7mol%-4-hydroxybutyrate] and poly[(R)-3-hydroxybutyrate-co-97mol%-4-hydroxybutyrate] were electrospun to fabricate scaffolds with enhanced biocompatibility and bioabsorption. Subcutaneous implantation of the fibers in rats was performed to investigate their bioabsorption behavior and tissue response. The fibers before and after the in vivo experiments were characterized using gel permeation chromatography, scanning electron microscopy, X-ray diffraction and tensile test. Histological evaluation was also performed to determine the tissue response. The structures and properties of the electrospun PHA copolymers were compared with those of the electrospun poly[(R)-3-hydroxybutyrate]. The content and type of the second monomer and the diameter of fiber significantly influence the bioabsorption. The tissue response was found to improve with the high content of 4-hydroxybutyrate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1307-17
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Scaffolds from electrospun polyhydroxyalkanoate copolymers: fabrication, characterization, bioabsorption and tissue response.
pubmed:affiliation
Bioengineering Laboratory, RIKEN Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't