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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1992-5-28
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pubmed:abstractText |
The levels of metronidazole in serum and tissue penetration of metronidazole were studied after prophylactic administration in 11 patients undergoing elective colorectal surgery. A single dose of 1,000 mg given intravenously was administered before surgery. Adequate drug levels in serum (greater than or equal to MIC for 90% of strains tested [MIC90] for Bacteroides fragilis) were found in all patients throughout the procedure. Mean peak (15-min) and last-determined (24-h) metronidazole levels in serum were 28.8 +/- 8 and 4.2 +/- 1.7 mg/liter, respectively. The beta-phase elimination half-life was 9.5 +/- 2.3 h, and the clearance and apparent volume of distribution were 57 +/- 13 ml/min and 0.7 +/- 0.1 liter/kg, respectively. In the colonic wall at surgical anastomosis, tissue metronidazole levels greater than or equal to MIC90 for B. fragilis were found in 91% of patients. In the abdominal wall fat and epiploic fat, tissue metronidazole levels greater than or equal to MIC90 for B. fragilis were found in 40 to 60% of patients at surgical incision and closure. No anaerobic infection occurred during the study.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-16722001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-2291657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-2659564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-341733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-3531863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-3535553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-372777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-3890436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-396633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-396639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-3980327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-4091530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-4688926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-4892316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-6252149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-6340904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-6380363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-6640241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-7147185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-7266633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-86666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1810194-90859
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0066-4804
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2602-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1810194-Aged,
pubmed-meshheading:1810194-Bacteroides fragilis,
pubmed-meshheading:1810194-Colon,
pubmed-meshheading:1810194-Female,
pubmed-meshheading:1810194-Humans,
pubmed-meshheading:1810194-Injections, Intravenous,
pubmed-meshheading:1810194-Intraoperative Period,
pubmed-meshheading:1810194-Male,
pubmed-meshheading:1810194-Metronidazole,
pubmed-meshheading:1810194-Middle Aged,
pubmed-meshheading:1810194-Premedication,
pubmed-meshheading:1810194-Rectum,
pubmed-meshheading:1810194-Tissue Distribution
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pubmed:year |
1991
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pubmed:articleTitle |
Pharmacokinetics and tissue penetration of a single 1,000-milligram, intravenous dose of metronidazole for antibiotic prophylaxis of colorectal surgery.
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pubmed:affiliation |
Department of Anesthesia and Intensive Care, Sainte Marguerite Hospital, Marseille, France.
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pubmed:publicationType |
Journal Article
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