Source:http://linkedlifedata.com/resource/pubmed/id/18087239
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
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umls-concept:C1705186,
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umls-concept:C2324195,
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umls-concept:C2700640,
umls-concept:C2911684
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| pubmed:dateCreated |
2007-12-18
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| pubmed:abstractText |
Light signals from rod and cone photoreceptors traverse distinct types of second-order, bipolar neurons that carry these signals from the outer to inner retina. Anatomic and physiologic studies suggest that the specialization of rod and cone bipolar cells involves the differential expression of proteins involved in glutamatergic signaling. In a previous study, we compared the expression of genes for the AMPA- (GluR1-4) and kainate-sensitive (GluR5-7, KA1-2) ionotropic glutamate receptors, the metabotropic glutamate receptors (mGluR1-8), and five non-vesicular glutamate transporters (EAAT1-5) in full-complement cDNA constructed from fresh and aldehyde-fixed macaque retina using a technique suitable for amplification of a variety of differentially expressed transcripts. Here we apply the same protocol to compare expression of these genes in cDNA constructed from single rod and cone bipolar cells previously-labeled for morphological identification in fixed slices of macaque retina.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1090-0535
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2194-208
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:18087239-Animals,
pubmed-meshheading:18087239-Cell Separation,
pubmed-meshheading:18087239-Female,
pubmed-meshheading:18087239-Gene Expression Regulation,
pubmed-meshheading:18087239-Gene Library,
pubmed-meshheading:18087239-Male,
pubmed-meshheading:18087239-Membrane Transport Proteins,
pubmed-meshheading:18087239-Polymerase Chain Reaction,
pubmed-meshheading:18087239-Primates,
pubmed-meshheading:18087239-Protein Subunits,
pubmed-meshheading:18087239-Receptors, Glutamate,
pubmed-meshheading:18087239-Retinal Bipolar Cells,
pubmed-meshheading:18087239-Retinal Cone Photoreceptor Cells,
pubmed-meshheading:18087239-Retinal Rod Photoreceptor Cells
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| pubmed:year |
2007
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| pubmed:articleTitle |
Expression of genes encoding glutamate receptors and transporters in rod and cone bipolar cells of the primate retina determined by single-cell polymerase chain reaction.
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| pubmed:affiliation |
The National Institute of Neurological Disorders and Stroke, National Institutes of Health, Cellular Neurology Unit, Bethesda, MD, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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