| pubmed-article:18067925 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18067925 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:18067925 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:18067925 | lifeskim:mentions | umls-concept:C1705323 | lld:lifeskim |
| pubmed-article:18067925 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:18067925 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:18067925 | lifeskim:mentions | umls-concept:C0015689 | lld:lifeskim |
| pubmed-article:18067925 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:18067925 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:18067925 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:18067925 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18067925 | pubmed:dateCreated | 2008-3-10 | lld:pubmed |
| pubmed-article:18067925 | pubmed:abstractText | Omega-3 fatty acids (n-3 FA) demonstrate significant anti-inflammatory properties thought to occur through three principal mechanisms; (1) displacement of arachidonic acid from the cellular membrane, (2) differential prostaglandin E2 (PGE2) and LTB4 production, and (3) molecular level alterations such as diminished nuclear factor kappa B and AP-1 activation. Recently, n-3 FA have been demonstrated to significantly decrease nitric oxide (NO) production in a lipopolysaccharide (LPS)-stimulated M Phi model. We hypothesized that decreased NO production by n-3 FA occurs through inhibition of cyclooxygenase-2 (COX-2) derived PGE2 and that repletion of the system with PGE2 would obliterate these effects. Selective COX-2 inhibitor (L-748,731) experiments and separate PGE2 repletion studies were used to test this hypothesis. | lld:pubmed |
| pubmed-article:18067925 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18067925 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18067925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18067925 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18067925 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18067925 | pubmed:issn | 0022-4804 | lld:pubmed |
| pubmed-article:18067925 | pubmed:author | pubmed-author:EspatN... | lld:pubmed |
| pubmed-article:18067925 | pubmed:author | pubmed-author:BabcockTricia... | lld:pubmed |
| pubmed-article:18067925 | pubmed:author | pubmed-author:RazzakAnthony... | lld:pubmed |
| pubmed-article:18067925 | pubmed:author | pubmed-author:SaiedAbdulA | lld:pubmed |
| pubmed-article:18067925 | pubmed:author | pubmed-author:AldrichChrisC | lld:pubmed |
| pubmed-article:18067925 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18067925 | pubmed:volume | 145 | lld:pubmed |
| pubmed-article:18067925 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18067925 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18067925 | pubmed:pagination | 244-50 | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:meshHeading | pubmed-meshheading:18067925... | lld:pubmed |
| pubmed-article:18067925 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18067925 | pubmed:articleTitle | Attenuation of iNOS in an LPS-stimulated macrophage model by omega-3 fatty acids is independent of COX-2 derived PGE2. | lld:pubmed |
| pubmed-article:18067925 | pubmed:affiliation | Department of Surgery, University of Illinois at Chicago, Chicago, Illinois 60612, USA. | lld:pubmed |
| pubmed-article:18067925 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18067925 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18067925 | lld:pubmed |
