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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-9
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pubmed:abstractText |
Indoles carrying a cyclic ester (gamma-butyrolactone) at C-3 position have been synthesized by the allylation of 3-indoleglyoxylate followed by iodocyclisation and the nucleophilic replacement of the iodo-group. Screening of these molecules for COX-2 inhibition and anti-cancer activities has identified compounds 10 and 11 as highly potent and selective for COX-2 as well as showing remarkable anti-cancer activities (better than that of indomethacin).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
85-9
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pubmed:meshHeading |
pubmed-meshheading:18061444-4-Butyrolactone,
pubmed-meshheading:18061444-Antineoplastic Agents,
pubmed-meshheading:18061444-Binding Sites,
pubmed-meshheading:18061444-Cell Line, Tumor,
pubmed-meshheading:18061444-Cyclooxygenase 2,
pubmed-meshheading:18061444-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:18061444-Drug Screening Assays, Antitumor,
pubmed-meshheading:18061444-Humans,
pubmed-meshheading:18061444-Indoles,
pubmed-meshheading:18061444-Models, Molecular,
pubmed-meshheading:18061444-Tosyl Compounds
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pubmed:year |
2008
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pubmed:articleTitle |
1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities.
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pubmed:affiliation |
Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. palwinder_singh_2000@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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