Source:http://linkedlifedata.com/resource/pubmed/id/18060776
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-1-21
|
| pubmed:abstractText |
Starting from the structure of 5, a two-step strategy was applied to identify a new generation of trifluoromethane sulfonamides as potent PPARalpha agonists. Synthesis, in vitro and in vivo evaluation of the most potent compound are reported.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
710-5
|
| pubmed:meshHeading |
pubmed-meshheading:18060776-Animals,
pubmed-meshheading:18060776-Cell Line,
pubmed-meshheading:18060776-Drug Design,
pubmed-meshheading:18060776-Drug Evaluation, Preclinical,
pubmed-meshheading:18060776-Humans,
pubmed-meshheading:18060776-Mice,
pubmed-meshheading:18060776-PPAR alpha,
pubmed-meshheading:18060776-Sulfonamides
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.
|
| pubmed:affiliation |
Department of Medicinal Chemistry, Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 avenue du Québec, 91951 Les Ulis, France. nicolas. faucher@gsk.com
|
| pubmed:publicationType |
Journal Article
|