|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0030685,
umls-concept:C0034289,
umls-concept:C0079189,
umls-concept:C0079904,
umls-concept:C0205314,
umls-concept:C0243077,
umls-concept:C0391871,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0679622,
umls-concept:C0680255,
umls-concept:C1158770,
umls-concept:C1283071,
umls-concept:C1456820,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1963578
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-1-21
|
|
pubmed:abstractText |
Novel heterocyclic ring-substituted pyrimidines have been designed as inhibitors of glycogen synthase kinase-3beta (GSK-3beta) from the modification of known inhibitors. Several potent inhibitors exhibiting nanomolar activities were discovered against GSK-3beta kinase as well as in an NF-kappaB reporter gene assay. Based on the results from in vitro TNF-alpha release inhibition and in vivo endotoxima, these inhibitors are expected to be useful candidates for treatment of inflammation-related diseases.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
653-6
|
|
pubmed:dateRevised |
2011-11-2
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Novel heterocycle-substituted pyrimidines as inhibitors of NF-kappaB transcription regulation related to TNF-alpha cytokine release.
|
|
pubmed:affiliation |
Department of Chemistry, Seoul National University, Seoul 151-747, Republic of Korea.
|
|
pubmed:publicationType |
Journal Article
|
