Linked Life Data

18053667

Source:http://linkedlifedata.com/resource/pubmed/id/18053667

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-17
pubmed:abstractText
During the past year, some novel genetic modifications were shown to alter the lifespan of mice, thus expanding the list of genes and physiological processes that influence mammalian aging. Considerable progress was also made in identifying putative mechanisms of extended longevity in previously described gene knockouts, mutants and transgenics. In addition, new leads concerning mechanisms of aging were derived from studies of gene knockout mice in which aging is accelerated. Among the important findings from the period July 2006 to July 2007: Core body temperature was shown to influence longevity in homeothermic animals; a Surf1 gene knockout extended lifespan in mice; separate studies using Little and Snell dwarf mice found stress resistance enhancements correlated with longevity gains; and mice heterozygous for deletion of insulin receptor substrate 2 (IRS-2) lived longer than normal animals, while animals with homozygous or heterozygous deletion of IRS-2 selectively in the brain exhibited comparable extension of lifespan and various symptoms of delayed aging.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0531-5565
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
New findings in gene knockout, mutant and transgenic mice.
pubmed:affiliation
Department of Internal Medicine and Physiology, Southern Illinois University School of Medicine, Springfield, IL 62794-9628, USA. abartke@siumed.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural