Linked Life Data

18048068

Source:http://linkedlifedata.com/resource/pubmed/id/18048068

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-21
pubmed:abstractText
Major depressive disorder is a major health problem in adults and is now recognized as a substantial problem in children as well. Tricyclic antidepressants, including desipramine (DMI), are no better than placebo in treating childhood and adolescent depression, but are effective in treating adult depression. Several studies have suggested that normal BDNF (brain-derived neurotrophic factor) signaling is necessary for antidepressant drug action. Antidepressant drugs induce several plastic changes in the rodent brain which may be associated with changes in BDNF levels and/or with BDNF function. In the present study we report parallel measurements of BDNF mRNA and protein in the frontal cortex and hippocampus after four days of twice daily treatments with escitalopram, a selective serotonin reuptake inhibitor, and desipramine, a tricyclic antidepressant. Post-natal day 13, 21, 28 and adult rats were used in this study. TrkB (the primary receptor for BDNF) mRNA levels were also examined under the same treatment conditions. BDNF mRNA and protein levels, as well as TrkB mRNA levels, were increased significantly in post-natal day 13 pups after escitalopram treatment as compared to control, but desipramine failed to increase either BDNF or TrkB. The failure of desipramine to increase BDNF and TrkB levels in juvenile rats is consistent with the lack of efficacy of desipramine in children and adolescents. The serotonergic nervous system matures earlier than the noradrenergic system, which may explain why escitalopram, but not desipramine, increases BDNF and TrkB levels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:18048068-Aging, pubmed-meshheading:18048068-Animals, pubmed-meshheading:18048068-Antidepressive Agents, Tricyclic, pubmed-meshheading:18048068-Brain-Derived Neurotrophic Factor, pubmed-meshheading:18048068-Chromatography, High Pressure Liquid, pubmed-meshheading:18048068-Citalopram, pubmed-meshheading:18048068-Desipramine, pubmed-meshheading:18048068-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:18048068-Hippocampus, pubmed-meshheading:18048068-Injections, Intraperitoneal, pubmed-meshheading:18048068-Prefrontal Cortex, pubmed-meshheading:18048068-RNA, Messenger, pubmed-meshheading:18048068-Rats, pubmed-meshheading:18048068-Receptor, trkB, pubmed-meshheading:18048068-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:18048068-Serotonin Uptake Inhibitors
pubmed:year
2008
pubmed:articleTitle
The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment.
pubmed:affiliation
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198-5800, USA. megankozisek@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural