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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0015576,
umls-concept:C0017258,
umls-concept:C0023745,
umls-concept:C0063695,
umls-concept:C0175630,
umls-concept:C0205147,
umls-concept:C0260832,
umls-concept:C0441889,
umls-concept:C0489835,
umls-concept:C0598077,
umls-concept:C1322652,
umls-concept:C1749467,
umls-concept:C1955970
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pubmed:issue |
1
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pubmed:dateCreated |
2008-6-24
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pubmed:abstractText |
Atherogenesis is a chronic inflammatory process in which intercellular adhesion molecule 1 (ICAM-1) plays a critical role. Circulating soluble ICAM-1 (sICAM-1) is thought to be the result of cleavage of membrane-bound ICAM-1 and its concentration in serum/plasma has been shown to be heritable. Genome-wide linkage scans were conducted for quantitative trait loci influencing sICAM-1. Phenotype and genetic marker data were available for 2617 white and 531 black individuals in the NHLBI Family Heart Study follow-up examination. Heritability for sICAM-1 was 0.39 in whites and 0.59 in blacks. Significant linkage was observed on chromosome 19 (LOD=4.0 at 14cM) in whites near the ICAM gene cluster that includes the structural gene for ICAM-1. The T-allele of ICAM-1 SNP rs5491 has been strongly associated with the specific sICAM-1 assay we used in our study. Through additional genotyping we were able to rule out rs5491 as the cause of the linkage finding. This study provides preliminary evidence linking genetic variation in the ICAM1 structural gene to circulating sICAM-1 levels.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/5 T32 HL007972,
http://linkedlifedata.com/resource/pubmed/grant/T32 HL007972-04,
http://linkedlifedata.com/resource/pubmed/grant/T32 HL007972-05,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56563,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56564,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56565,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56566,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56567,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56568,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56569,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67893,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67894,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67895,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67896,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67897,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67898,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67899,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67900,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67901,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67902
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-10620617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-11037320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-11055364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-11137085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-11583751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-11731797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-12111669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-14733921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-15326567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-15502096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-16159603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-16292665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-16625213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-1682385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-8116623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-8506304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-9326339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-9416885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-9433606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-9433616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-9439492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-9545414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18045607-9598845
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1879-1484
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pubmed:author |
pubmed-author:ArnettDonna KDK,
pubmed-author:BielinskiSuzette JSJ,
pubmed-author:EckfeldtJohn HJH,
pubmed-author:FosterCatherine LeiendeckerCL,
pubmed-author:HixsonJimJ,
pubmed-author:HopkinsPaul NPN,
pubmed-author:LiuYongmeiY,
pubmed-author:MillerMichael BMB,
pubmed-author:MyersRichard HRH,
pubmed-author:PankowJames SJS,
pubmed-author:RegisterTomT
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pubmed:issnType |
Electronic
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pubmed:volume |
199
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
172-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18045607-Humans,
pubmed-meshheading:18045607-Follow-Up Studies,
pubmed-meshheading:18045607-European Continental Ancestry Group,
pubmed-meshheading:18045607-Aged,
pubmed-meshheading:18045607-African Continental Ancestry Group,
pubmed-meshheading:18045607-Female,
pubmed-meshheading:18045607-Male,
pubmed-meshheading:18045607-Adult,
pubmed-meshheading:18045607-Atherosclerosis,
pubmed-meshheading:18045607-Middle Aged,
pubmed-meshheading:18045607-Phenotype,
pubmed-meshheading:18045607-Solubility,
pubmed-meshheading:18045607-Genotype,
pubmed-meshheading:18045607-Genetic Linkage,
pubmed-meshheading:18045607-Vasculitis
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