Linked Life Data

18040076

Source:http://linkedlifedata.com/resource/pubmed/id/18040076

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-18
pubmed:abstractText
In previous studies, collagen XI mRNA has been detected in colon cancer, but its location in human colon tissue has not been determined. The heterotrimeric collagen XI consists of three alpha chains. While it is known that collagen XI plays a regulatory role in collagen fibril formation, its function in the colon is unknown. The characterization of normal human colon tissue will allow a better understanding of the variance of collagen XI in abnormal tissues. Grossly normal and malignant human colon tissue was obtained from pathology archives. Immunohistochemical staining with a 58K Golgi marker and alpha1(XI) and alpha2(XI) antisera was used to specifically locate their presence in normal colon tissue. A comparative bright field microscopic analysis showed the presence of collagen XI in human colon. The juxtanuclear, dot-like collagen XI staining in the Golgi apparatus of goblet cells in normal tissue paralleled the staining of the 58K Golgi marker. Ultra light microscopy verified these results. Staining was also confirmed in malignant colon tissue. This study is the first to show that collagen XI is present in the Golgi apparatus of normal human colon goblet cells and localizes collagen XI in both normal and malignant tissue. Although the function of collagen XI in the colon is unknown, our immunohistochemical characterization provides the foundation for future immunohistopathology studies of the colon.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/AR-47985, http://linkedlifedata.com/resource/pubmed/grant/AR-48672, http://linkedlifedata.com/resource/pubmed/grant/K02 AR048672-01, http://linkedlifedata.com/resource/pubmed/grant/K02 AR048672-02, http://linkedlifedata.com/resource/pubmed/grant/K02 AR048672-03, http://linkedlifedata.com/resource/pubmed/grant/K02 AR048672-04, http://linkedlifedata.com/resource/pubmed/grant/K02 AR048672-05, http://linkedlifedata.com/resource/pubmed/grant/P-20RR-016454, http://linkedlifedata.com/resource/pubmed/grant/P20 RR016454-086155, http://linkedlifedata.com/resource/pubmed/grant/P20 RR016454-096114, http://linkedlifedata.com/resource/pubmed/grant/R01 AR047985-01, http://linkedlifedata.com/resource/pubmed/grant/R01 AR047985-02, http://linkedlifedata.com/resource/pubmed/grant/R01 AR047985-03, http://linkedlifedata.com/resource/pubmed/grant/R01 AR047985-04, http://linkedlifedata.com/resource/pubmed/grant/R01 AR047985-05
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1554
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-83
pubmed:dateRevised
2010-3-19
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Immunohistochemical localization of collagen type XI alpha1 and alpha2 chains in human colon tissue.
pubmed:affiliation
Department of Biology, Northwest Narzarene University, Nampa, Idaho, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural