Linked Life Data

18032003

Source:http://linkedlifedata.com/resource/pubmed/id/18032003

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-3-3
pubmed:abstractText
During development from juvenility to adulthood, rats displayed constant vitamin B12, decreasing folic acid and increasing homocysteine levels in blood plasma parallel to decreasing aminopeptidase M activities in the jejunum. The rising homocysteine level with advancing age implies growing metabolic stress and may be seen as cause for the increase of the number of cleft lip alveolus palate at pregnancies in higher age. Similarly, additional morphologic changes of the villi and crypta were regarded to reflect age-related adaptation of the digestive tract. Thus, the rat model is interesting for human-relevant studies of metabolic diseases or fetal anomalies, as in man these parameters develop likewise with increasing age. Sufficient supply of B vitamins is an important factor for a normal course of pregnancy, healthy offsprings and physiologic blood parameters and is essential to a stable methylation cycle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0940-2993
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Growth-related changes of parameters of the methylation cycle and jejunal aminopeptidase M in the rat.
pubmed:affiliation
Institute for Anatomy and Cell Biology, Ernst-Moritz-Arndt-University, Friedrich-Löffler-Strasse 23c, D-17487 Greifswald, Germany.
pubmed:publicationType
Journal Article