|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2007-11-20
|
|
pubmed:abstractText |
Chronic lymphocytic leukemia (CLL) cells, like normal B-cells, exist in two populations in vivo: quiescent cells in the peripheral circulation and proliferating cells in lymph nodes. The surface marker CD38 has roles in cell adhesion and signaling. Its expression correlates with poor clinical outcome and is associated with expression of the signaling intermediate ZAP-70, which is also a marker of poor prognosis. We investigated the regulation of CD38 and ZAP-70 in proliferating CLL cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1592-8721
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
92
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1359-66
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:18024373-Antibodies,
pubmed-meshheading:18024373-Antigens, CD38,
pubmed-meshheading:18024373-CD40 Ligand,
pubmed-meshheading:18024373-Cell Proliferation,
pubmed-meshheading:18024373-Humans,
pubmed-meshheading:18024373-Interleukin-4,
pubmed-meshheading:18024373-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:18024373-Tumor Cells, Cultured,
pubmed-meshheading:18024373-ZAP-70 Protein-Tyrosine Kinase
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4.
|
|
pubmed:affiliation |
Division of Investigative Sciences, Department of Haematology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
