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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1992-4-28
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pubmed:abstractText |
Thirty-two patients with metastatic colorectal cancer were entered in a phase II study of ACNU as first-line treatment. ACNU was given at a dose of 100 mg/m2 i.v. every six weeks. In 30 evaluable patients we observed partial responses lasting 5 and 8 months in 2 patients with liver metastases, and stable disease in 4 patients. The toxicity mainly consisted of leuco- and trombocytopenia. We conclude that in this dose and schedule ACNU has only very limited activity in metastatic colorectal cancer.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0923-7534
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
767-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1801885-Adenocarcinoma,
pubmed-meshheading:1801885-Adult,
pubmed-meshheading:1801885-Aged,
pubmed-meshheading:1801885-Colorectal Neoplasms,
pubmed-meshheading:1801885-Drug Evaluation,
pubmed-meshheading:1801885-Female,
pubmed-meshheading:1801885-Humans,
pubmed-meshheading:1801885-Liver Neoplasms,
pubmed-meshheading:1801885-Lung Neoplasms,
pubmed-meshheading:1801885-Male,
pubmed-meshheading:1801885-Middle Aged,
pubmed-meshheading:1801885-Nimustine,
pubmed-meshheading:1801885-Soft Tissue Neoplasms
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pubmed:articleTitle |
Phase II study of ACNU as first-line treatment in advanced colorectal cancer.
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pubmed:affiliation |
Department of Medical Oncology, Rotterdam Cancer Center/Dr. Daniel den Hoed Kliniek, The Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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