Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-1-7
pubmed:abstractText
Heparan sulfate proteoglycans modulate signaling by a variety of growth factors. The mammalian proteoglycan Perlecan binds and regulates signaling by Sonic Hedgehog, Fibroblast Growth Factors (FGFs), Vascular Endothelial Growth Factor (VEGF) and Platelet Derived Growth Factor (PDGF), among others, in contexts ranging from angiogenesis and cardiovascular development to cancer progression. The Drosophila Perlecan homolog trol has been shown to regulate the activity of Hedgehog and Branchless (an FGF homolog) to control the onset of stem cell proliferation in the developing brain during first instar. Here we extend analysis of trol mutant phenotypes to show that trol is required for a variety of developmental events and modulates signaling by multiple growth factors in different situations.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-10349625, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-10446222, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-10545953, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-10579729, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-10631185, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-10704828, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-10824099, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-11101850, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-11279527, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-11311169, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-11356148, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-11489925, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-11847221, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-11941538, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-12142349, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-12186645, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-12203732, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-12435733, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-12586708, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-12645928, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-12818570, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-12929089, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-14602069, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-14991716, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-15256433, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-15381778, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-1551575, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-15563523, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-15590745, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-15774861, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-15944190, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-16064139, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-16072037, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-16077094, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-16507112, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-16750652, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-16943280, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-1901786, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-3119399, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-4366476, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-7743929, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-7916657, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-8062386, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-8393416, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-9121441, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-9335506, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-9550723, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-9788974, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-98369, http://linkedlifedata.com/resource/pubmed/commentcorrection/17980035-9842718
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1471-213X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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