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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-4-16
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pubmed:abstractText |
1. The hyperalgesic effects of interleukin-8 (IL-8), interleukin-1 beta (IL-1 beta) and carrageenin were measured in a rat paw pressure test. 2. IL-8 evoked a dose-dependent hyperalgesia which was attenuated by a specific antiserum, the beta-adrenoceptor antagonists atenolol and propranolol, the dopamine receptor antagonist SCH 23390 and the adrenergic neurone-blocking agent guanethidine. The hyperalgesia was not attenuated by the cyclooxygenase inhibitor indomethacin or the IL-1 beta analogue Lys-D-Pro-Thr. 3. IL-1 beta-evoked hyperalgesia was attenuated by indomethacin and Lys-D-Pro-Thr but not by atenolol or SCH 23390. 4. Carrageenin-evoked hyperalgesia was attenuated by atenolol, indomethacin and anti-IL-8 serum. The effects of atenolol and anti-IL-8 serum were not additive. The effects of indomethacin and anti-IL-8 serum were additive: this combination abolished carrageenin-evoked hyperalgesia. 5. A new biological activity of IL-8 is described, namely the capacity to evoke hyperalgesia by a prostaglandin-independent mechanism. IL-8 is the first endogenous mediator to be identified as evoking hyperalgesia involving the sympathetic nervous system. Since IL-8 is released by activated macrophages and endothelial cells it may be a humoral link between tissue injury and sympathetic hyperalgesia.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-13611696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-14269604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-215920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-2663015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-2672824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-2688092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-2783447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-2884117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-310771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-3137474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-3203167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-4133701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-5284360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-6424083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1797337-6783230
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
765-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1797337-Animals,
pubmed-meshheading:1797337-Atenolol,
pubmed-meshheading:1797337-Benzazepines,
pubmed-meshheading:1797337-Carrageenan,
pubmed-meshheading:1797337-Dinoprostone,
pubmed-meshheading:1797337-Edema,
pubmed-meshheading:1797337-Foot,
pubmed-meshheading:1797337-Guanethidine,
pubmed-meshheading:1797337-Interleukin-1,
pubmed-meshheading:1797337-Interleukin-8,
pubmed-meshheading:1797337-Male,
pubmed-meshheading:1797337-Monocytes,
pubmed-meshheading:1797337-Nociceptors,
pubmed-meshheading:1797337-Pain,
pubmed-meshheading:1797337-Propranolol,
pubmed-meshheading:1797337-Rats,
pubmed-meshheading:1797337-Rats, Inbred Strains,
pubmed-meshheading:1797337-Recombinant Proteins,
pubmed-meshheading:1797337-Sympathetic Nervous System
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pubmed:year |
1991
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pubmed:articleTitle |
Interleukin-8 as a mediator of sympathetic pain.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Medicine, Sao Paulo, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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