Linked Life Data

17964155

Source:http://linkedlifedata.com/resource/pubmed/id/17964155

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2007-11-16
pubmed:abstractText
To identify novel inhibitors of tyrosinase, a fluorescent assay was developed which is suitable for high-throughput screening. In the assay, oxidation of the substrate by tyrosinase leads to the release of a fluorescent coumarin. Several small molecules were identified that inhibited mushroom tyrosinase in vitro and human tyrosinase in cell culture. These compounds may represent lead structures for therapies targeted at disorders of hyperpigmentation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6871-5
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Discovery of small-molecule inhibitors of tyrosinase.
pubmed:affiliation
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't