Source:http://linkedlifedata.com/resource/pubmed/id/17962017
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
2007-11-16
|
| pubmed:abstractText |
The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on TNF-alpha and IL-6 secretion in mouse macrophages were also evaluated. Most of the tested compounds showed inhibitory effects, and the compounds with the structure of 12-hydroxy-14-dehydroandrographolide showed better inhibitory activity than the compounds with the structure of isoandrographolide.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6891-4
|
| pubmed:meshHeading |
pubmed-meshheading:17962017-Animals,
pubmed-meshheading:17962017-Cell Line,
pubmed-meshheading:17962017-Diterpenes,
pubmed-meshheading:17962017-Interleukin-6,
pubmed-meshheading:17962017-Macrophages,
pubmed-meshheading:17962017-Mice,
pubmed-meshheading:17962017-Molecular Structure,
pubmed-meshheading:17962017-Structure-Activity Relationship,
pubmed-meshheading:17962017-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Synthesis of andrographolide derivatives and their TNF-alpha and IL-6 expression inhibitory activities.
|
| pubmed:affiliation |
Center of Drug Discovery, College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
|
| pubmed:publicationType |
Journal Article
|