rdf:type |
|
lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0017562,
umls-concept:C0019628,
umls-concept:C0023516,
umls-concept:C0037083,
umls-concept:C0059239,
umls-concept:C0086418,
umls-concept:C0086597,
umls-concept:C0456387,
umls-concept:C1565434,
umls-concept:C1710082
|
pubmed:issue |
6
|
pubmed:dateCreated |
2007-10-24
|
pubmed:abstractText |
The role of human leukocyte antigen class II molecules on nonantigen-presenting cells has been a matter of controversy. We previously reported that human leukocyte antigen class II molecules on human gingival fibroblasts do not present antigens, but transduce signals into the cells by making a complex with antigenic peptide T-cell receptor or by stimulating cell surface human leukocyte antigen-DR molecules with human leukocyte antigen-DR antibody (L243), which mimics the formation of the human leukocyte antigen class II-antigenic peptide T-cell receptor complex, resulting in the expression of several cytokines. The aim of this study was to detect human leukocyte antigen class II-associated molecules mediating human leukocyte antigen class II-induced signals into the cells.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
D
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0022-3484
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
42
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
572-9
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:17956472-Cells, Cultured,
pubmed-meshheading:17956472-Chemokine CCL2,
pubmed-meshheading:17956472-Chemokine CCL5,
pubmed-meshheading:17956472-Fibroblasts,
pubmed-meshheading:17956472-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:17956472-Gingiva,
pubmed-meshheading:17956472-HLA-D Antigens,
pubmed-meshheading:17956472-HLA-DR Antigens,
pubmed-meshheading:17956472-Humans,
pubmed-meshheading:17956472-Interleukin-6,
pubmed-meshheading:17956472-Luteolin,
pubmed-meshheading:17956472-Phosphorylation,
pubmed-meshheading:17956472-Protein Array Analysis,
pubmed-meshheading:17956472-Signal Transduction
|
pubmed:year |
2007
|
pubmed:articleTitle |
Focal adhesion kinase mediates human leukocyte histocompatibility antigen class II-induced signaling in gingival fibroblasts.
|
pubmed:affiliation |
Department of Patho-physiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|