Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-11
pubmed:abstractText
Hepatitis C virus-positive serum (HCVser, genotypes 1a to 3a) or HCV cell culture (JFH1/HCVcc) infection of primary normal human hepatocytes was assessed by measuring intracellular HCV RNA strands. Anti-CD81 antibodies and siRNA-CD81 silencing markedly inhibited (>90%) HCVser infection irrespective of HCV genotype, viral load, or liver donor, while hCD81-large intracellular loop (LEL) had no effect. However, JFH1/HCVcc infection of hepatocytes was modestly inhibited (40 to 60%) by both hCD81-LEL and anti-CD81 antibodies. In conclusion, CD81 is involved in HCVser infection of human hepatocytes, and comparative studies of HCVser versus JFH1/HCVcc infection of human hepatocytes and Huh-7.5 cells revealed that the cell-virion combination is determinant of the entry process.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-10729140, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-10775621, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-11024134, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-11679585, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-11991950, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12072493, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12134024, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12356718, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12424921, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12464260, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12477859, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12518064, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12525620, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12609975, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12615904, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12692255, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12706076, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12761383, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12766998, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12867431, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-12913001, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-1312126, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-15123813, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-15147380, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-15382119, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-15613294, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-15630458, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-15660396, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-15939869, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-15947137, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-15951748, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-16628670, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-16719400, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-16928753, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-16943299, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-17156886, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-17325668, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-17462692, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-17518369, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-7494326, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-7665862, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-8030225, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-8121333, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-9402948, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-9780041, http://linkedlifedata.com/resource/pubmed/commentcorrection/17942559-9794763
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1098-5514
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569-74
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
More...