Linked Life Data

17931931

Source:http://linkedlifedata.com/resource/pubmed/id/17931931

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2007-10-12
pubmed:abstractText
The aim of this research was to study the effects of estrogen deficiency on the receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) synthesis in the periapical lesions that were induced in ovariectomized (OVX) and sham-ovariectomized (Sham) rats. After mandibles were collected, the enzyme histochemical test for tartrate-resistant acid phosphatase and immunohistochemical examination for RANKL and OPG were performed. On days 0, 7, and 28, the numbers of osteoclasts in the periapical areas of the OVX rats were significantly more than those of the Sham group. The data had statistical differences on days 7, 21, and 28 for RANKL-positive cells between the 2 groups. The number of OPG-positive cells of the OVX rats was more than that of the Sham group at the early stage of estrogen deficiency (day 7). Estrogen deficiency-induced severe periapical bone resorption might be mediated by overexpression of RANKL. At the early stage of estrogen deficiency, the osteoblastogenesis was also accelerated, which was shown as a kind of reactive protective response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0099-2399
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1053-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The effect of estrogen deficiency on receptor activator of nuclear factor kappa B ligand and osteoprotegerin synthesis in periapical lesions induced in rats.
pubmed:affiliation
School and Hospital of Stomatology, Tongji University, Shanghai City, P. R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't