Linked Life Data

17925812

Source:http://linkedlifedata.com/resource/pubmed/id/17925812

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-10-19
pubmed:abstractText
In a small fraction of mammalian genes--at present estimated at less than 1% of the total--one of the two alleles that is inherited by the offspring is partially or completely switched off. The decision as to which one is silenced depends on which allele was inherited from the mother and which from the father. These idiosyncratic loci are known as imprinted genes, and their existence is an evolutionary enigma, as they effectively nullify the advantages of diploidy. Although they are small in number, these genes have important effects on physiology and behaviour, and many are expressed in the brain. There is increasing evidence that imprinted genes influence brain function and behaviour by affecting neurodevelopmental processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1471-0048
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
832-43
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Genomic imprinting effects on brain development and function.
pubmed:affiliation
Behavioural Genetics Group, School of Psychology and Department of Psychological Medicine, School of Medicine, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK. wilkinsonl@cardiff.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't