17901954

Source:http://linkedlifedata.com/resource/pubmed/id/17901954

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007600, umls-concept:C0086418, umls-concept:C0205177, umls-concept:C0205314, umls-concept:C0205531, umls-concept:C0226896, umls-concept:C0231491, umls-concept:C0248266, umls-concept:C0281361, umls-concept:C0442027, umls-concept:C0598934, umls-concept:C0679622, umls-concept:C0680730, umls-concept:C1148554, umls-concept:C1280500, umls-concept:C1510779, umls-concept:C1515655, umls-concept:C1524059, umls-concept:C1527415, umls-concept:C1533691, umls-concept:C1831827
pubmed:issue	5
pubmed:dateCreated	2008-2-21
pubmed:abstractText	Gastrin is known to enhance the growth of pancreatic carcinoma via the cholecystokinin (CCK)-2/gastrin receptor. We investigated the anti-tumor effect of Z-360 (calcium bis [(R)-(-)-3-[3-{5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl}ureido]benzoate]), a novel orally active CCK-2 receptor antagonist alone or combined with the chemotherapeutic agent, gemcitabine in human pancreatic adenocarcinoma cell lines.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7806519
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Benzodiazepinones, http://linkedlifedata.com/resource/pubmed/chemical/Deoxycytidine, http://linkedlifedata.com/resource/pubmed/chemical/Gastrins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cholecystokinin B, http://linkedlifedata.com/resource/pubmed/chemical/Z-360, http://linkedlifedata.com/resource/pubmed/chemical/gastrin 17, http://linkedlifedata.com/resource/pubmed/chemical/gemcitabine
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0344-5704
pubmed:author	pubmed-author:EmoriYutakaY, pubmed-author:HamanoHirokiH, pubmed-author:IinoYukaY, pubmed-author:KawasakiDaisukeD, pubmed-author:Ro?zI EIE, pubmed-author:TakeiMineoM, pubmed-author:TanakaTakaoT, pubmed-author:WatsonSusan ASA, pubmed-author:YoshinagaKojiK
pubmed:issnType	Print
pubmed:volume	61
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	883-92
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:17901954-Adenocarcinoma, pubmed-meshheading:17901954-Administration, Oral, pubmed-meshheading:17901954-Animals, pubmed-meshheading:17901954-Antineoplastic Agents, pubmed-meshheading:17901954-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:17901954-Benzodiazepinones, pubmed-meshheading:17901954-Cell Line, Tumor, pubmed-meshheading:17901954-Cell Proliferation, pubmed-meshheading:17901954-Deoxycytidine, pubmed-meshheading:17901954-Disease Models, Animal, pubmed-meshheading:17901954-Female, pubmed-meshheading:17901954-Gastrins, pubmed-meshheading:17901954-Humans, pubmed-meshheading:17901954-Mice, pubmed-meshheading:17901954-Mice, Nude, pubmed-meshheading:17901954-Pancreatic Neoplasms, pubmed-meshheading:17901954-Phosphorylation, pubmed-meshheading:17901954-Proto-Oncogene Proteins c-akt, pubmed-meshheading:17901954-Receptor, Cholecystokinin B, pubmed-meshheading:17901954-Survival Rate, pubmed-meshheading:17901954-Xenograft Model Antitumor Assays
pubmed:year	2008
pubmed:articleTitle	Effect of Z-360, a novel orally active CCK-2/gastrin receptor antagonist on tumor growth in human pancreatic adenocarcinoma cell lines in vivo and mode of action determinations in vitro.
pubmed:affiliation	Central Research Laboratories, Zeria Pharmaceutical Co., Ltd, 2512-1, Numagami, Oshikiri, Kumagaya-city, Saitama 360-0111, Japan.
pubmed:publicationType	Journal Article