Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-9-25
pubmed:abstractText
Epithelial-mesenchymal transition (EMT), crucial during embryogenesis for new tissue and organ formation, is also considered to be a prerequisite to cancer metastasis. We report here that the protein tyrosine phosphatase Pez is expressed transiently in discrete locations in developing brain, heart, pharyngeal arches, and somites in zebrafish embryos. We also find that Pez knock-down results in defects in these organs, indicating a crucial role in organogenesis. Overexpression of Pez in epithelial MDCK cells causes EMT, with a drastic change in cell morphology and function that is accompanied by changes in gene expression typical of EMT. Transfection of Pez induced TGFbeta signaling, critical in developmental EMT with a likely role also in oncogenic EMT. In zebrafish, TGFbeta3 is co- expressed with Pez in a number of tissues and its expression was lost from these tissues when Pez expression was knocked down. Together, our data suggest Pez plays a crucial role in organogenesis by inducing TGFbeta and EMT.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-10355033, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-10655587, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-10733523, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-10864463, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-10887508, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-10934049, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-10949939, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-11309385, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-11430829, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-11533493, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-11598958, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-11689706, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-12142029, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-12167406, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-12189386, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-12213733, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-12508111, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-12808048, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-12808151, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-12861075, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-14623443, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-14701881, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-15084492, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-15155950, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-15210113, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-15345668, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-15349812, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-15739231, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-15942196, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-16107477, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-16123809, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-16177030, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-16728569, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-2586525, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-3259578, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-7493022, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-8167376, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-8464695, http://linkedlifedata.com/resource/pubmed/commentcorrection/17893246-9007238
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense, http://linkedlifedata.com/resource/pubmed/chemical/PTPN14 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases, http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases..., http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Smad4 Protein, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta2, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta3, http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1223-35
pubmed:dateRevised
2011-3-2
pubmed:meshHeading
pubmed-meshheading:17893246-Humans, pubmed-meshheading:17893246-Animals, pubmed-meshheading:17893246-Dogs, pubmed-meshheading:17893246-Embryo, Nonmammalian, pubmed-meshheading:17893246-Mesoderm, pubmed-meshheading:17893246-Epithelial Cells, pubmed-meshheading:17893246-Embryonic Development, pubmed-meshheading:17893246-Cell Nucleus, pubmed-meshheading:17893246-RNA, Messenger, pubmed-meshheading:17893246-Phenotype, pubmed-meshheading:17893246-Protein Transport, pubmed-meshheading:17893246-Gene Expression Regulation, Developmental, pubmed-meshheading:17893246-Signal Transduction, pubmed-meshheading:17893246-Zebrafish Proteins, pubmed-meshheading:17893246-Transcription Factors, pubmed-meshheading:17893246-Zebrafish, pubmed-meshheading:17893246-Protein Tyrosine Phosphatases, pubmed-meshheading:17893246-Transforming Growth Factor beta, pubmed-meshheading:17893246-Transforming Growth Factor beta2, pubmed-meshheading:17893246-Oligonucleotides, Antisense, pubmed-meshheading:17893246-Transforming Growth Factor beta1, pubmed-meshheading:17893246-Protein Tyrosine Phosphatases, Non-Receptor
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