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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-10-8
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pubmed:abstractText |
Uterine decidualization is crucial for successful implantation and the establishment of pregnancy. In the present study, the expression of insulin-like growth factor-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) in the human uterus and endometrial stromal cells (ESCs) and its physiological significance in decidualization were examined. IGFBP-rP1 protein was localized in the glandular epithelium and stromal cells, and blood vessels in the endometrium. Cultured stromal cells expressed IGFBP-rP1 and secreted it into the medium. IGFBP-rP1 was localized mostly in the cytoplasm near the nucleus. Knocking down the endogenous IGFBP-rP1 expression in stromal cells, by a small interfering (si)RNA, diminished the expression of prolactin and IGFBP-1 which serve as decidual markers. These results suggest that IGFBP-rP1 may play a role in decidualization of ESCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1360-9947
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
737-43
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pubmed:meshHeading |
pubmed-meshheading:17884839-Adult,
pubmed-meshheading:17884839-Blotting, Western,
pubmed-meshheading:17884839-Cells, Cultured,
pubmed-meshheading:17884839-Decidua,
pubmed-meshheading:17884839-Endometrium,
pubmed-meshheading:17884839-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17884839-Female,
pubmed-meshheading:17884839-Humans,
pubmed-meshheading:17884839-Insulin-Like Growth Factor Binding Protein 1,
pubmed-meshheading:17884839-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:17884839-Pregnancy,
pubmed-meshheading:17884839-Prolactin,
pubmed-meshheading:17884839-RNA, Small Interfering,
pubmed-meshheading:17884839-RNA Interference,
pubmed-meshheading:17884839-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17884839-Stromal Cells,
pubmed-meshheading:17884839-Uterus
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pubmed:year |
2007
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pubmed:articleTitle |
Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells.
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pubmed:affiliation |
Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Hachioji-Shi, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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