Source:http://linkedlifedata.com/resource/pubmed/id/17849314
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2007-9-12
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| pubmed:abstractText |
It has been suggested that terminally differentiated neuronal cells and mitotic cells respond differently in many aspects to herpes simplex virus type 1 (HSV-1) infection. The ICP4-deleted, Us3-defective, HSV-1 mutant strain d120 induces classical apoptosis in a variety of mitotic cell lines. Its behavior in postmitotic cells is not known. Here the authors report that mutant d120 virus failed to induce apoptosis in neuronal-like, nerve growth factor (NGF)-differentiated PC12 cells. More strikingly, rather than inducing apoptosis, d120 infection prolonged the life of nondividing NGF-differentiated PC12 cells in the culture flask. The virus genome had a half-life of 30 days. Unlike in other cells, such as Vero, neither wild-type nor d120 infection of NGF-differentiated PC12 cells induced the nuclear factor (NF)-kappa B p65 pathway, which has been associated with virus-induced apoptosis. Thus, the authors demonstrate, for the first time, that a potent apoptosis inducer mutant d120 failed to induce apoptosis in neuronal-like NGF-differentiated PC12 cells, unlike a number of other cell lines studied. The possible mechanisms involved in the failure of d120 to induce apoptosis in neuronal-like NGF-differentiated PC12 cells are discussed.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/US3 protein, Human herpesvirus 1,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/herpes simplex virus, type 1...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1355-0284
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
305-14
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| pubmed:meshHeading |
pubmed-meshheading:17849314-Animals,
pubmed-meshheading:17849314-Apoptosis,
pubmed-meshheading:17849314-Carcinoma, Hepatocellular,
pubmed-meshheading:17849314-Cell Differentiation,
pubmed-meshheading:17849314-Cell Line, Tumor,
pubmed-meshheading:17849314-Cercopithecus aethiops,
pubmed-meshheading:17849314-Gene Deletion,
pubmed-meshheading:17849314-Herpes Simplex,
pubmed-meshheading:17849314-Herpesvirus 1, Human,
pubmed-meshheading:17849314-Humans,
pubmed-meshheading:17849314-Immediate-Early Proteins,
pubmed-meshheading:17849314-Kidney Neoplasms,
pubmed-meshheading:17849314-Nerve Growth Factor,
pubmed-meshheading:17849314-Neurons,
pubmed-meshheading:17849314-PC12 Cells,
pubmed-meshheading:17849314-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17849314-Rats,
pubmed-meshheading:17849314-Transcription Factor RelA,
pubmed-meshheading:17849314-Vero Cells,
pubmed-meshheading:17849314-Viral Proteins
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| pubmed:year |
2007
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| pubmed:articleTitle |
Herpes simplex virus type 1 ICP4 deletion mutant virus d120 infection failed to induce apoptosis in nerve growth factor-differentiated PC12 cells.
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| pubmed:affiliation |
Drexel Institute for Biotechnology and Virology Research and Department of Microbiology and Immunology, College of Medicine, Drexel University, Doylestown, Pennsylvania, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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