Linked Life Data

17846139

Source:http://linkedlifedata.com/resource/pubmed/id/17846139

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-10-22
pubmed:abstractText
The objective of these analyses was to assess the penetration of tigecycline into colon wall tissue and epithelial lining fluid (ELF). The analyses included data from subjects without infection (phase 1) and patients with intra-abdominal infections (phase 2/3). Steady-state serum samples were collected from all subjects/patients (n = 577), while colon wall specimens (n = 23) and ELF specimens (n = 30) were obtained from subjects without infection. Tissue and serum data were simultaneously comodeled by using the BigNPAG program, and a four-compartment, open model with zero-order intravenous input and first-order elimination was employed. To examine the full range of tissue penetration and the associated probabilities of occurrence, a 9,999-subject Monte Carlo simulation was performed with two outputs, one for ELF penetration and one for colon wall tissue penetration. Data were well fit using models described above, with all r(2) values above 0.95. For subjects without infection, the median (5th and 95th percentiles) colon wall and ELF penetration ratios were 1.73 (0.160 and 199) and 1.15 (0.561 and 5.23), respectively. Simulation results predict that tissue penetration varies considerably and likely explain unexpected clinical outcomes for those patients infected with strains at margins of the MIC distribution.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-10898674, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-11796385, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-15156435, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-15616299, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-15885987, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-16940069, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-17012300, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-1948795, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-8384815, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-8452359, http://linkedlifedata.com/resource/pubmed/commentcorrection/17846139-9174209
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4085-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Evaluation of tigecycline penetration into colon wall tissue and epithelial lining fluid using a population pharmacokinetic model and Monte Carlo simulation.
pubmed:affiliation
Institute for Clinical Pharmacodynamics, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Multicenter Study