Source:http://linkedlifedata.com/resource/pubmed/id/17823984
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2007-10-2
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pubmed:abstractText |
IL-15 is thought to be involved in the pathogenesis of rheumatoid arthritis (RA). We found that IL-15 plays an important role in the development of murine collagen-induced arthritis (CIA). The incidence and severity of CIA were slightly decreased in IL-15 KO mice but were increased in IL-15 Tg mice compared with wild-type (WT) mice. The levels of type II collagen (CII)-specific IL-17 production were significantly increased in IL-15 Tg mice compared with WT mice with CIA. Expression of IL-23R was up-regulated in CD4(+) T cells in IL-15 Tg mice but down-regulated in IL-15 KO mice compared with WT mice. In correlation with the expression levels of IL-23R, IL-17 production by CD4(+) T cells in response to exogenous IL-23 was increased in IL-15 Tg mice compared with WT mice. Furthermore, exogenous IL-15 synergized with IL-23 to induce CII-specific IL-17 production by CD4(+) T cells in vitro. Taken together, these results indicate that IL-15 plays an important role in the progression of CIA through increasing antigen-specific IL-17 production by CD4(+) T cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-2980
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2744-52
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pubmed:meshHeading |
pubmed-meshheading:17823984-Animals,
pubmed-meshheading:17823984-Arthritis, Experimental,
pubmed-meshheading:17823984-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17823984-Cells, Cultured,
pubmed-meshheading:17823984-Collagen Type II,
pubmed-meshheading:17823984-Epitopes, T-Lymphocyte,
pubmed-meshheading:17823984-Interleukin-15,
pubmed-meshheading:17823984-Interleukin-17,
pubmed-meshheading:17823984-Lymphocyte Activation,
pubmed-meshheading:17823984-Male,
pubmed-meshheading:17823984-Mice,
pubmed-meshheading:17823984-Mice, Inbred C57BL,
pubmed-meshheading:17823984-Mice, Knockout,
pubmed-meshheading:17823984-Mice, Transgenic
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pubmed:year |
2007
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pubmed:articleTitle |
IL-15 exacerbates collagen-induced arthritis with an enhanced CD4+ T cell response to produce IL-17.
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pubmed:affiliation |
Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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