|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2007-9-20
|
|
pubmed:abstractText |
In our previous studies that examined in vivo activities of oncostatin M (OM) in upregulation of hepatic LDL receptor (LDLR) expression, we observed reductions of LDL-cholesterol and triglyceride (TG) levels in OM-treated hyperlipidemic hamsters. Interestingly, the OM effect of lowering plasma TG was more pronounced than LDL-cholesterol reduction, suggesting additional LDLR-independent actions. Here, we investigated mechanisms underlying the direct TG-lowering effect of OM.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ACSL5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Coenzyme A Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/OSM protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Oncostatin M,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/long-chain-fatty-acid-CoA ligase
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1524-4636
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2198-205
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:17761945-Animals,
pubmed-meshheading:17761945-Cell Line, Tumor,
pubmed-meshheading:17761945-Cholesterol, Dietary,
pubmed-meshheading:17761945-Coenzyme A Ligases,
pubmed-meshheading:17761945-Cricetinae,
pubmed-meshheading:17761945-Disease Models, Animal,
pubmed-meshheading:17761945-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:17761945-Fatty Acids,
pubmed-meshheading:17761945-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17761945-Humans,
pubmed-meshheading:17761945-Hypertriglyceridemia,
pubmed-meshheading:17761945-Lipid Metabolism,
pubmed-meshheading:17761945-Liver,
pubmed-meshheading:17761945-Oncostatin M,
pubmed-meshheading:17761945-Oxidation-Reduction,
pubmed-meshheading:17761945-RNA, Messenger,
pubmed-meshheading:17761945-RNA, Small Interfering,
pubmed-meshheading:17761945-RNA Interference,
pubmed-meshheading:17761945-Recombinant Proteins,
pubmed-meshheading:17761945-Signal Transduction,
pubmed-meshheading:17761945-Time Factors,
pubmed-meshheading:17761945-Transcriptional Activation,
pubmed-meshheading:17761945-Transfection,
pubmed-meshheading:17761945-Triglycerides
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation.
|
|
pubmed:affiliation |
VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|
